Lipedema patients will often experience pain in the lipedemic region. A significant difference between lipedema and general fat storage is that regardless of an individual’s weight loss effort there will be no change in the volume of the lipedemic region, even with minimal food intake.
Lipedema occurs more frequently in women and tends to be localized to areas such as the thigh, buttocks, lower abdomen, and sometimes the arms, while hands and feet are unaffected and remain slim.   Lipedemicregions are at risk for cellulitis, fungal, and bacterial infections.
Manual Lymphatic Drainage (MLD) and Combined Decongestive Therapy (CDT) are indicated to treat lipedema. Compression bandaging or garments are often difficult for individuals to tolerate due to the area being painful, however MLD, because of its gentle nature is often effective for reducing both the volume of the edema and the pain associated with the lipedema. MLD/CDT do not eliminate the extra adipose tissue.